PSU Mark
Eberly College of Science Mathematics Department

Meeting Details

For more information about this meeting, contact Tim Reluga, Stephanie Zerby, Andrew Belmonte, Chun Liu.

Title:Optimal Within-Host Treatment and the Role of Resource Mediated Competitive Release
Seminar:Mathematical Biology and Physiology Seminar
Speaker:Elsa Hansen, CIDD, at Penn State
Experimental results show that treatment can actually accelerate the growth of resistant pathogens via the mechanism of competitive release. It is unknown how treatment should be administered in order to mediate this effect while maintaining health gains. I will discuss an ongoing project where I am applying Pontryagin's Maximum Principle to a within-host model of disease spread to determine how competitive release can modulate the shape of the optimal treatment strategy. I will begin with a brief review of Pontryagin's Maximum Principle and then discuss my progress to date.

Room Reservation Information

Room Number:MB114
Date:02 / 14 / 2014
Time:12:00pm - 01:00pm