Center for Interdisciplinary Mathematics
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Previous talk

Time:Nov. 10, 2015, 1:30pm-2:30pm.
Place:106 McAllister Building.
Speaker: Herbert Levine, Center for Theoretical Biological Physics, Rice University
Title:Models of cell motility: From the single cell to the collective sheet
Abstract:

Cell motility is essential for many biological processes including wound healing, immune response, and cancer metastasis. For cells crawling on surfaces, motility involves a complex interplay between acto-myosin based force generation, adhesion to the substrate and chemical-based polarization to determine a direction. Here, we discuss our work aimed at developing integrative computational models of cell motility, ranging in complexity from simple geometrical models to complex phase-field approaches coupled to cytoskeletal mechanics. We also discuss initial efforts at using single cell models to understand the collective behavior of motile cells when they interact.