Center for Interdisciplinary Mathematics
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Previous talk

Time:Nov. 10, 2015, 1:30pm-2:30pm.
Place:106 McAllister Building.
Speaker: Herbert Levine, Center for Theoretical Biological Physics, Rice University
Title:Models of cell motility: From the single cell to the collective sheet

Cell motility is essential for many biological processes including wound healing, immune response, and cancer metastasis. For cells crawling on surfaces, motility involves a complex interplay between acto-myosin based force generation, adhesion to the substrate and chemical-based polarization to determine a direction. Here, we discuss our work aimed at developing integrative computational models of cell motility, ranging in complexity from simple geometrical models to complex phase-field approaches coupled to cytoskeletal mechanics. We also discuss initial efforts at using single cell models to understand the collective behavior of motile cells when they interact.