For more information about this meeting, contact Kris Jenssen.
| Title: | Mathematical Modeling of Cellular Signaling in Macrophages: Understanding the Pathways |
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| Seminar: | Computational and Applied Mathematics Colloquium |
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| Speaker: | Mary Ann Horn, NSF and Department of Mathematics, Vanderbilt University |
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| Abstract: |
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| Our goal is the construction of a comprehensive mathematical model for the
uridine 5'-diphosphate (UDP) signaling pathway in the RAW 264.7
macrophage, a type of white blood cell. This mathematical model
incorporates modules for: (i) the ligand interaction with the P2Y6
receptor, the putative mode of action for UDP; (ii) the subsequent
G-protein cascade; (iii) the activation of effector enzymes including
phospholipase C (PLC), diacylglycerol kinase (DGK), and several forms of
phosphatidylinositol kinase (PI4K, PI5K). In addition, small molecule
dynamics for Ca2+, IP3, and PIPn are either modeled or used as functional
inputs to provide a comprehensive description of the signaling dynamics.
Our model focuses on diacylglycerol (DAG) and phosphatidic acid (PA), and
lipidomic technology is utilized to measure the formation and fate of
these important lipid second messengers. Modeling techniques, challenges,
and computational simulations will be presented. (Joint work with Hannah
L. Callender, Dianne L. DeCamp, Paul C. Sternweis, and H. Alex Brown.) |
Room Reservation Information
| Room Number: | MB106 |
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| Date: | 11 / 13 / 2009 |
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| Time: | 03:35pm - 04:25pm |
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