PSU Mark
Eberly College of Science Mathematics Department

Meeting Details

For more information about this meeting, contact Sergei Tabachnikov, Flossie Dunlop.

Title:Can understanding cancer be translated into effective anticancer therapy?
Seminar:MASS Colloquium
Speaker:Andrei Gudkov, Roswell Park Cancer Institute, Buffalo, NY
Abstract:
Multicellular organisms, such as human, can be viewed as a social society of cells differing in their professional skills and functions with all major properties of social system in place (birth, growth, education, choice of profession, ageing, death, etc.). Rules of social behavior determining stability and functionality of the society involve strict multifold negative control over cell multiplication and place of residence by external (immune system, an equivalent of law enforcing agencies) and internal (mechanisms of self-evaluation, an equivalent of personal moral rules and cell ageing) mechanisms. In extreme cases of cell "misbehavior" these mechanisms may lead to enforced or suicidal cell death. Cancer development requires not only loss of normal response to negative growth regulation (equivalents of criminals) but also acquisition by tumor cells the ability to avoid regulated cell death. All the above-mentioned mechanisms are relatively well understood as a result of recent advancements of molecular and cellular biology. However, the majority of currently used cancer treatment approaches were developed long before these mechanisms become understood. Perspectives and principles of translation of new knowledge of mechanisms into effective cancer treatment strategies and new anticancer drugs will be presented and discussed.

Room Reservation Information

Room Number:MB113
Date:11 / 01 / 2007
Time:02:30pm - 03:20pm