PSU Mark
Eberly College of Science Mathematics Department

Meeting Details

For more information about this meeting, contact Sergei Tabachnikov.

Title:DNA Topology
Seminar:MASS Colloquium
Speaker:De Witt Sumners, Florida State University
Abstract:
Cellular DNA is a long, thread-like molecule with remarkably complex topology. Enzymes that manipulate the geometry and topology of cellular DNA perform many vital cellular processes (including segregation of daughter chromosomes, gene regulation, DNA repair, and generation of antibody diversity). Some enzymes pass DNA through itself via enzyme-bridged transient breaks in the DNA; other enzymes break the DNA apart and reconnect it to different ends. In the topological approach to enzymology, circular DNA is incubated with an enzyme, producing an enzyme signature in the form of DNA knots and links. By observing the changes in DNA geometry (supercoiling) and topology (knotting and linking) due to enzyme action, the enzyme binding and mechanism can often be characterized. This talk will discuss the tangle model for site-specific recombination.

Room Reservation Information

Room Number:MB113
Date:11 / 06 / 2008
Time:02:30pm - 03:20pm