For more information about this meeting, contact Andrew Belmonte, Tim Reluga, Stephanie Zerby, Chun Liu.
|Title:||Divots in Extracellular Geometry Direct Intracellular Signaling|
|Seminar:||Mathematical Biology and Physiology Seminar|
|Speaker:||Bradford E. Peercy, Department of Mathematics and Statistics, University of Maryland Baltimore County|
|The cellular decision to migrate depends on cascades of intracellular signals initiated by extracellular stimuli. In the biological model system of Drosophila melanogaster, border cells in the epithelium of the developing egg chamber are triggered to migrate or not depending on a secreted morphogen Unpaired. We will describe and discuss our modeling work in three steps of this process: 1) Secretion-diffusion-uptake of Unpaired into-through-from a heterogeneous extracellular domain, 2) Intracellular signaling involving chemical competition and bistability to induce motility, and 3) Force generation between activated cells and their environment to create clustered cell migration.
We can address questions such as what is the effect of microRNAs on the intracellular signaling? Can we explain clustered cell migration with basic force balance dynamics? Are divots creating additional extracellular space sufficient to explain the variety of asymmetric activation patterns seen in prior to migration? This last question will be the main focus of the talk.
This work was conducted as part of the NSF UBM grant to UMBC with undergraduates Xuan Ge, David Stonko, Ann Marie Weideman, and Bilal Moiz, graduate student Lathiena Manning, and faculty co-mentor Dr. Michelle Starz-Gaiano|
Room Reservation Information
|Date:||04 / 11 / 2014|
|Time:||12:00pm - 01:00pm|