PSU Mark
Eberly College of Science Mathematics Department

Meeting Details

For more information about this meeting, contact Andrew Belmonte, Hope Shaffer.

Title:Nanoscale stepping dynamics of the molecular motor kinesin
Seminar:Seminar on Mathematics in the Bio and Geo Sciences
Speaker:Will Hancock, Dept of Bioengineering, Penn State
Abstract:
Kinesins are a class of mechanoenzymes that walk along microtubules in cells, carrying intracellular cargo including vesicles and chromosomes to appropriate destinations in the cell. These motors can be studied in single-molecule assays, using mutagenesis to study the role of the different mechanical components that make up the motor. We are studying how the two heads of kinesin take their 8 nm steps and focusing on the role of tethered diffusion during the walking cycle. I will review the basic biology of motor proteins and the cytoskeleton, experimental work, and analytical and computational modeling approaches we are using. Time permitting, I will also give an overview of the microengineering and dielectrophoresis studies we are carrying out to manipulate microtubules in vitro.

Room Reservation Information

Room Number:MB106
Date:09 / 28 / 2011
Time:01:00pm - 02:00pm